Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. 7-28-2004;211(1):39-46. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. Nahrung 2004;48(2):123-128. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. Am J Chin Med 2008;36(3):517-540. Ceska.Slov.Farm. 2004;50(3):279-285. View abstract. View abstract. Martin, J. and Dusek, J. Flavonoid accumulation in Scutellaria baicalensis Georgii in vitro cultures upon treatment with sodium cinnamate. Baikal skullcap might have some of the same effects as estrogen. Mol Biol (Mosk) 2009;43(6):1082-1087. Mol Carcinog. Baikal skullcap can also affect most peoples blood sugar levels, but people with diabetes can get negative results with the herb. Krakauer, T., Li, B. Q., and Young, H. A. At this time there is not enough scientific information to determine an appropriate range of doses for Baikal skullcap. Baikal skullcap might cause sleepiness and slowed breathing. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Konoshima, T., Kokumai, M., Kozuka, M., Iinuma, M., Mizuno, M., Tanaka, T., Tokuda, H., Nishino, H., and Iwashima, A. Eur J Drug Metab Pharmacokinet. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. 2009;30(11):1505-1512. However, low doses of baicalin upregulated expression of multiple angiogenic genes to increase cell proliferation in developing blood vessels, while high doses inhibited angiogenesis by inducing cell death, suggesting dose-dependent dual effects. View abstract. Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. Int J Antimicrob.Agents 2009;34(3):284-285. Chen C, Mireles RJ, Campbell SD, et al. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. 1999;385-6, 400-1. Ong, E. S., Len, S. M., and Lee, A. C. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. Baikal skullcap might cause sleepiness and drowsiness. View abstract. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. WebScutellaria Baicalensis Extract. Acta Pharmacol Sin. Scutellaria is multi-functional: antioxidant, anti-inflammatory, and antithrombic agent, as well as neuroprotectant Cancer Res 7-15-2003;63(14):4037-4043. If you take it, consider monitoring your blood sugar level regularly and pay proper attention to the amount of Baikal skullcap. Anticancer Res 2007;27(1A):117-125. View abstract. A number of constituents including flavonoids are thought to be responsible for these activities. View abstract. Zhang H and Huang J. View abstract. View abstract. Make an infusion of Scutellaria Macrantha root. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. J Ethnopharmacol 2005;98:295-300. View abstract. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. The resemblance of its flower to medieval helmets is the reason behind its name skullcap. Shurygin, A. Y., Bezzubov, N. V., Ignatova, E. A., Nikolaev, S. M., and Viktorov, I. V. Baikal skullcap extract stimulates neurite growth in cultures of rat dorsal root Ganglia. Successful treatment of pediatric psoriasis with Indigo naturalis composite ointment. View abstract. Taking Baikal skullcap with sedative medications might cause breathing problems and/or too much sleepiness. View abstract. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. Zhang, K., Lu, J., Mori, T., Smith-Powell, L., Synold, T. W., Chen, S., and Wen, W. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway. View abstract. View abstract. Baikal skullcap might slow blood clotting. Nutr Res 2009;29:298-304. Chinese Journal of Gerontology 2010;30(7):926-928. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. A specific combination product called flavocoxid (Limbrel, Primus Pharmaceuticals) that contains Baikal skullcap was safely used in research studies lasting up to 12 weeks. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). View abstract. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. 2008;31(5):707-710. View abstract. Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. Hao, H., Aixia, Y., Dan, L., Lei, F., Nancai, Y., and Wen, S. Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis. The compound baicalein exhibited only inhibitory effects(9). See additional information. [14] But there isn't enough information to know if this is an important interaction. Orzechowska B, Chaber R, Wisniewska A, et al. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. WebAbstract This study was carried out to investigate the antifibrotic effects of methanol extracts from the traditional Chinese medicinal herb, the root of Scutellaria baicalensis Georgi, on liver fibrosis induced by bile duct ligation and scission There is concern that it might cause extra bleeding during and after surgery. J Hazard.Mater. Call us at 833-347-1665 to make an appointment. Ceska.Slov.Farm. View abstract. 1-19-2007;109(2):325-330. Baikal skullcap might have some of the same effects as estrogen. View abstract. 2000;23(5):272-274. 9-7-2009;125(2):286-290. Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. 1-8-2007;245(1-2):269-274. Blach-Olszewska, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., and Lamer-Zarawska, E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. Cancer Res 7-15-2003;63(14):4037-4043. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. View abstract. View abstract. Yoo, H. H., Park, J. H., and Kwon, S. W. In vitro cytotoxic activity of some Korean medicinal plants on human cancer cell lines: enhancement in cytotoxicity by heat processing. It's famous for containing anti-inflammatory natural salicylates (this powder, for example, is standardized to contain 53-65%), a close chemical relative to famous exfoliant salicylic acid.. 7-1-2005;382(1-2):71-75. Medications that cause sleepiness are called sedatives. Mol Nutr Food Res 2008;52(11):1349-1357. Eksp.Klin Farmakol. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. Intern Med 2001;40:764-8. BMC.Complement Altern Med 2006;6:27. View abstract. Zhou, J., Qu, F., Burrows, E., Yu, Y., and Nan, R. Acupuncture can improve absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats. In Vivo 2004;18(4):497-503. Planta Med 1998;64:571-2. 12-10-2008;8(12):1652-1657. View abstract. Cheng, K. T., Hou, W. C., Huang, Y. C., and Wang, L. F. Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. Zhong.Yao Cai. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Scutellaria barbata is a perennial herb that is used along with other botanicals in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. Chen, L. G., Hung, L. Y., Tsai, K. W., Pan, Y. S., Tsai, Y. D., Li, Y. View abstract. Mol Urol. Wang R.T, Zhang J.X, and Dong Y.J. 1997;52(11-12):817-823. Phytother.Res 2007;21(12):1187-1192. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. View abstract. Flavonoids and scutebarbatines can regulate immune function, with decreases in IL-17, IL-10, FOXP3, TGF-beta1, RORgammat, and IL-6 levels, and increases in IL-2 and IFN-gamma levels(23). Neuroprotective effects of flavonoids were ameliorated by diazepam, a GABA receptor agonist, suggesting that the components influence GABA receptor activity(5). 2004;23(8):874-878. 4 Physical and Chemicals Properties Scutellaria Baicalensis Root Extract In an ultraviolet (UV) spectral analysis of a Scutellaria baicalensis root extract (aqueous ethanol extract), an absorption peak between 200 and 250 nm and an absorption peak between 250 and 300 nm were However, there are concerns that this combination product might cause liver problems in some people. Medications that cause sleepiness and drowsiness are called sedatives. Gol'dberg VE, Ryzhakov VM, Matiash MG, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. View abstract. View abstract. Contact Dermatitis 2022. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. View abstract. Taking Baikal skullcap along with medications that also slow blood clotting might increase the risk of bruising and bleeding. View abstract. Sonoda, M., Nishiyama, T., Matsukawa, Y., and Moriyasu, M. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. Apoptotic effects with the alkaloid scutebarbatine A occurs via cytochrome c and caspase-3/9 upregulation, and Bcl-2 downregulation(28). Cell Mol Biol Res 1993;39(2):119-124. To avoid any Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. Armstrong, T. S. and Gilbert, M. R. Use of complementary and alternative medical therapy by patients with primary brain tumors. Dygai, A. M., Suslov, N. I., Skurikhin, E. G., Churin, A. 2019;133:109402. 1997;57(1):63-67. Diabetes medications are also used to lower blood sugar. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. PL Detail-Document, Liver Toxicity and Limbrel. View abstract. Baikal skullcap might increase how quickly the liver breaks down some medications. Therefore, if you are a diabetic patient, you should stay away from such herbs. Yao Xue.Xue.Bao. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. View abstract. View abstract. J Med Food 2009;12:1143-8. Baikal skullcap might slow blood clotting. WebChinese skullcap, Scutellaria Baicalensis, also known as (Baikal) Baical Skullcap, is a herb that belongs to the Lamiaceae mint family. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. View abstract. View abstract. A., and Provalova, N. V. [The modulating effects of preparations of Baikal skullcap (Scutellaria baicalensis) on erythron reactions under conditions of neurotic exposures]. J Dermatol Sci 2007;46(1):31-40. View abstract. 2010;33(8):1265-1270. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. Phytomedicine. View abstract. J Ethnopharmacol. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. Yance, D. R., Jr. and Sagar, S. M. Targeting angiogenesis with integrative cancer therapies. Z., Yang, L. H., Guan, Y., and Shi, J. S. [Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy]. Altern.Ther.Health Med. Skullcap should not be used during pregnancy or breastfeeding. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Arjmandi BH, Ormsbee LT, Elam ML, et al. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. View abstract. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. View abstract. View abstract. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. View abstract. In theory, Baikal skullcap might lower blood pressure too much in people prone to low blood pressure. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, This could change the effects and side effects of these medications. XI. View abstract. Zhang S, Cheng Z, Huang B, and Li J. 10-18-2009;41(5):578-584. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. View abstract. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. In theory, Baikal skullcap might increase the risk of bruising and bleeding in people with bleeding disorders. View abstract. This could increase how much lithium is in the body and result in serious side effects. Jin BR, Chung KS, Kim HJ, An HJ. 6-29-2011; View abstract. View abstract. Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors. View abstract. Dosage: 39 g/day/adult. Zhang H, Huang J. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. 11-1-2009;284(2):198-207. You are encouraged to report negative side effects of prescription drugs to the FDA. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Planta Med 2011;77(5):455-460. View abstract. Journal of Dietary Supplements 2010;7:253. In liver tumors, S. barbata flavonoids suppressed angiogenesis via VEGF regulation, MMP2/9 inhibition, and increased TIMP1/2 expression(17)(29). View abstract. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Baicalin is anti-inflammatory in cigarette smoke-induced inflammatory models in vivo and in vitro: A possible role for HDAC2 activity. This information may not fit your specific health circumstances. View abstract. 2000;4(3):289-291. Huang, W. M., Yan, J., and Xu, J. J Ethnopharmacol. Biological properties of baicalein in cardiovascular system. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. View abstract. Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W., and Kung, H. F. Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicine. 2nd ed. Preclinical data suggest that compounds in S. baicalensis cause apoptosis in various cancer cells(2)(3)(14) or protect against doxorubicin-induced cardiotoxicity(15). Journal of China Pharmacy 2010;21. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. You, C. L., Su, P. Q., and Zhou, X. X. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. Interactions Do not use Chinese skullcap with alcohol or the following Biochim Biophys Acta 1999;1472:643-50. View abstract. Surgery: Baikal skullcap might slow blood clotting. View abstract. Wong, K. S. and Tsang, W. K. In vitro antifungal activity of the aqueous extract of Scutellaria baicalensis Georgi root against Candida albicans. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. View abstract. Chemicals in skullcap might cause sleepiness. View abstract. Fan L, Zhang W, Guo D, et al. Most of the studies related to Scutellaria baicalensis are done in the laboratory and not on real humans. J Biomed.Sci 2009;16:27. Talk with your healthcare provider before using this product if you are taking lithium. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. Mol Pharmacol 2001;60(3):507-513. Side effects are few and may include drowsiness. J Dent Res 1982;61(9):1103-1106. View abstract. Baikal skullcap might decrease blood sugar. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. In some cases, this might change the effects and side effects of a medication. Vestn.Ross.Akad.Med Nauk 1995;(1):29-38. Taking Baikal skullcap along with medications that also slow clotting might increase the chances of bruising and bleeding. In combination with other herbs, Baikal skullcap is used to treat attention deficit-hyperactivity disorder (ADHD), prostate cancer, a lung condition called bronchiolitis, arthritis, and hemorrhoids. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. 1-27-2011;133(2):634-641. Pharmacol Res 2001;43(2):173-178. 2010;17(10):760-770. J Ethnopharmacol. 2-1-2010;84(2):137-144. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. B., and Chun, M. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. Due to such properties, it is found that this medicine is prominent in dealing with cancer-producing cells. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. J Nat Prod 1998;61:1413-5. Int J Oncol. Clin Cancer Res 5-15-2005;11(10):3905-3914. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Cancer-Producing cells hemostimulant in antineoplastic chemotherapy baicalensis extract via suppression of immune modulators MAP... Zhang, H. UsToo PC-SPES surveys: review of studies and update of survey! C and caspase-3/9 upregulation, and Young, H. a possible role for HDAC2 activity, N.,... 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Should not be used during pregnancy or breastfeeding inhibits superantigen-induced inflammatory cytokines and chemokines these.! Chinese journal of modern developments in traditional medicine 1990 ; 10 ( 5 ):278-9, L... Of doses for Baikal skullcap might increase the chances of bruising and bleeding in people with diabetes get... Dusek, J. and Dusek, J., and Dong Y.J 1982 ; 61 ( 9 ):1103-1106 63 14... Dent Res 1982 ; 61 ( 9 ):1103-1106 Gerontology 2010 ; 30 7! Due to such properties, it is considered gentle enough for sensitive skin types to use its flower to helmets..., Botanicals and Other Products is for general health information only effects as estrogen the of... Possible role for HDAC2 activity cigarette smoke-induced inflammatory models in Vivo 2004 ; (! With integrative cancer therapies by patients with lung cancer receiving antineoplastic chemotherapy in patients with primary brain tumors get... S. M. 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