Normal ranges for these elements for Indian population have not been defined in literature which could explain this. Clinica Chimica Acta 1972;32:207-11. https://www.pigmentinternational.com/text.asp?2021/8/1/30/313135, Pigment International | Published by Wolters Kluwer -. Alternative medicines, such as vitamin supplementation, are also very effective in treating vitiligo, as vitiligo patients often suffer from vitamin D, folic acid, vitamin B12, copper, and zinc deficiencies. News-Medical. Turmeric is loaded with powerful antioxidant properties and helps eliminate toxins from the body. Results: A highly significant increase (p = 0.000) in the copper level was seen in vitiligo patients compared with the control group. On the similar lines, Helmy et al. Table 1 Zinc and copper reference ranges as per kit inserts, Table 2 Comparison of Zn and copper levels in cases and controls, Table 3 Correlation of serum Zinc and Copper levels with the patient variables, Table 4 Correlation of serum Zinc and Copper levels with the patient variables. Z Hautkr 1987;62:1064, 9-72, 75. Patients often rely on topical applications and vitamin supplementation to lessen the appearance of patches and keep the skin healthy. Vitiligo occurs when cells that produce . The metabolism of copper is regulated by a range of proteins, including the copper transporter 1 (CTR1), the copper chaperone for superoxide dismutase (CCS), and the ATP7A and ATP7B copper-transporting ATPases. Researchers have been suggesting that vitiligo may be a result of autoimmunity, genetic, oxidative stress or neural causes. Our study shows lower mean levels of serum Zn in cases than controls. The age of the cases ranged from 5-62 years, mean age being 26.1 years. Serum Zn and Cu were estimated by photometric analysis. They also concluded that topical corticosteroid plus oral zinc sulfate had no preference over topical corticosteroid only. Can The Risk of Developing Vitiligo be Increased Due to Exposure to Household Chemicals? Diotallevi F, Campanati A, Martina E, Radi G, Paolinelli M, Marani A, Molinelli E, Candelora M, Taus M, Galeazzi T, Nicolai A, Offidani A. Nutrients. Mumbai: Bhalani publishing house; 2008. p. 736-798. [11] observed significantly lower levels of Zn. Indian J Dermatol 2006;51:100-4. By continuing to browse this site you agree to our use of cookies. Copper vitiligo: needed for melanin production; low levels found in many with vitiligo; low levels lead to . ginkgo biloba. [9] as mentioned above. Normally, the color of hair and skin is determined by melanin. Wolters Kluwer Health, Inc. and/or its subsidiaries. Although the relationship between copper deficiency and pigmentation has been established in many studies, the association between vitiligo and copper levels still needs to be investigated more thoroughly. Research has increased significantly to more clearly define and plan quicker and more effective treatments for the condition, and there is a belief that genetic and biomedical technology provide promising areas in the development of improved initial understanding, and treatment of, vitiligo. Hence, keeping these roles and the proposed theories in mind it has been often hypothesized that abnormal serum Zn and Cu levels may have a role to play in pathophysiology of vitiligo. Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. analyse site usage and support us in providing free open access scientific content. The prevalence of vitiligo is 0.1% to 3% in different ethnic and racial groups. amino acids. with these terms and conditions. A pure copper bracelet is believed to possess properties that ease pain and inflammation in the body. Does copper has a role in vitiligo? The study was conducted on patients suffering from vitiligo attending a hospital in Uttar Pradesh, India between July 1996 and June 1998. Chin J of Derm Venereol 1991;1:20-21, 65. 0000002180 00000 n Wolters Kluwer Health [5] Also, the synthesis of melanin involves rate-limiting catalytic step the enzyme tyrosinase which requires Cu for its activity. Moreover, vitiligo may co-occur with other autoimmune disorders, such as hypo- or hyper-thyroidism, diabetes, adrenocortical insufficiency, rheumatoid arthritis, and pernicious anemia. "Vitamin Supplementation for Vitiligo". In a Chinese meta-analysis of 16 studies, by Zeng et al,[4] 14 studies evaluated serum Zn within which four studies reported no statistically significant difference in Zn levels between the vitiligo group and the healthy group, ten studies presented significant decrease and none found increased Zn levels. Vitiligo is an acquired disorder of skin and mucous membrane characterized by well circumscribed, depigmented macules which occurs secondary to destruction of melanocytes. Analysis of tissue and serum copper in vitiligo') + "&publicationDate=" + encodeURI ('Jan 1 2021 12:00AM') + "&author=" + encodeURI ('Archana S, Rangappa V, Savitha T, Jayadev B, Kushalappa P, Ashwini P') + "&contentID=" + encodeURI ('PigmentInt_2021_8_1_30_313135') + "&orderBeanReset=true" 18, 19 Besides its physical manifestations, vitiligo has psychosocial implications. Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. J Clin Aesthet Dermatol. 8600 Rockville Pike It also has antioxidant properties that prevent free radicals and ions from raising toxicity. Minimizes the risk of cancer and anemia. I bought copper supplements 3 mg just started taking it. Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. Generalized vitiligo, in which patches appear on many parts of the skin. We wish to create an understanding of the role lipids play in vitiligo and schizophrenia, as well as the association of these conditions with oxidative stress and metabolic syndrome. It also helps in maintaining the immune system; a vitamin D deficiency has been observed in many autoimmune disorders. Would you suggest I drink from a copper vessel? The study found that 64% of participants experienced an increase in skin color, and the treatment was well-tolerated with no adverse effects reported. Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. The authors believed that increased apoptosis of PBMCs (Polymorphous blood mononuclear cells) led to the release of Zn and Cu in serum, resulting in increasing their serum levels significantly in active vitiligo. Various studies have been conducted to elucidate their role but none of them have clearly established this. Asian women described feeling visibly different and all had experienced stigmatization to some extent. eCollection 2022. Results: Of 60 patients, serum Cu levels in cases were found to be low in 35, normal in 22 and high in 3. Arch Dermatol 1999;135:407-13. These were not on any oral Zn and Cu supplements. Nutritional deficiencies are known to alter melanin production. Am J Clin Nutr 1996;63:797S-811S. Copper (Cu) is a trace element that is required in minutely small doses. In our study, mean serum levels of Cu were significantly higher in cases than in controls. Some people report their patches getting less visible with the use of copper bracelets while some others even noticed their patches disappearing with long-term use. Copper bracelets are known to be highly beneficial for vitiligo patients and provide a plethora of other health benefits, lowering the risks of other ailments and keeping the skin healthy and young. 0 Of the . This water contains copper ions that help increase melanin production in the body and reduce the appearance of white patches caused by vitiligo. A bracelet made out of pure copper can boost immunity and energy levels to a great extent. This common exercise makes you look OLDER (Avoid this popular exercise) Functional nutrition as integrated approach in vitiligo management. Journal of the Indian Medical Association 1961;37:593-7. Indian J Dermatol Venereol Leprol 2010;76:231-8. Trace elements levels in serum and hair of patients with vitiligo and alopecia areata. Moreover, various factors affect Zn and Cu levels in serum, so empirical treatment with Zn and Cu supplements increases the cost of treatment and is not supported by evidence. Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. Serum Zn and Cu were estimated by photometric analysis. Mean serum Zn was found highest in vulgaris type and lowest in segmental type and mean serum Cu was found highest in segmental type and lowest in acrofacial type. The interactions of genetic, immunological, microbiological, and environmental factors can induce disease development and progression, but there is still a lack of information . Aim: To estimate serum and tissue copper levels in vitiligo patients, and to compare with first degree relatives of patients and control group. However, Shameer et al. Applying a corticosteroid cream to affected skin might return color. Would you like email updates of new search results? Vitiligo patients should consider applying aloe vera gel to their affected skin areas regularly to lighten the patches and get better skin. National Library of Medicine In conclusion, the evidence suggests that copper deficiency may play a role in the development and progression of vitiligo by impairing melanin production and contributing to oxidative stress. There was no correlation between levels of Zn and Cu with each other in cases with Spearmans rho 0.22 and P=0.026 and controls with Spearmans rho=0.09 and P=0.502. Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. 0000001269 00000 n Recently, studies have proposed a link between copper metabolism and vitiligo, suggesting that copper deficiency may be a contributing factor to the development and progression of the disease. Some take vitamins like vitamin B12 and vitamin D, or antioxidants like vitamin E, beta-carotene, and vitamin C in the hope that they will improve their vitiligo. Tu CX, Lin XR, Yin F. Copper and zinc contents in serum and skin tissue liquid from patients with vitiligo. Koranne RV, Derm D, Sachdeva KG. S.A. Archana, Vinutha Rangappa, T.G. Your are viewing optimised page for portable devives, to see detailed version click here. startxref Background: Vitiligo is an acquired, primary, idiopathic disorder characterized by depigmented macules and patches. Hi thank you for your comment about your vitiligo experience with copper which was an ingredient in Boost. disease, Addison disease, copper deficiency, parasitosis, and diabetes mellitus .18,19 Besides it s physical manifestations, vitiligo has psychosocial implications. The analysis of variance (ANOVA) was also performed to compare the quantitative variables with three or more groups. Preliminary observations suggest that the presence of gluten in the diet may play a role in vitiligo development in some patients, but to date vitiligo-specific diets have not been studied. Further, and Bruske and Salfeld[10] and Shameer et al. Therefore, we undertook a study to evaluate serum Zn and Cu levels in vitiligo. [3], Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. Ashwini Finally, I decided to create a shop site too where all the items I had found beneficial could be found in one place: Vitiligo Store. Health Qual Life Outcomes 2003;23:1-58. Possible side effects include skin thinning or the appearance of streaks or lines on your . Materials and Methods: All cases of vitiligo attending tertiary care hospital were included in the study. Lesions often start on sun-exposed areas [2]. [13] even though the response in the group treated with topical steroid-oral zinc combination was more than the group with the steroid alone there was no statistically significant difference between the two groups. Other triggering factors include sunburn, environmental or industrial chemicals, and stress. Gopal k, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P, Srikant. In: valia RG, Valia AR, eds. However, empirical treatment with Zn and Cu supplements increases the cost of treatment and is not supported by any evidence. eCollection 2021. Results: Among 100 cases, the serum Zn level was increased in 58%, normal in 41%, and low in the remaining 1%, whereas in the control group, the level was increased in all 60 subjects. Age of controls ranged from 8 to 64 years, mean age being 29.3 years. Kyriakis KP, Palamaras I, Tsele E, Michailides C, Terzoudi S. Case detection rates of vitiligo by gender and age. Supplementing with copper can benefit vitiligo patients with deficiency and slow down the progression of the disorder. In addition to this, though the Chinese meta-analysis showed lower Cu and Zn levels, the efficacy evaluation of supplemental Cu or Zn in the treatment of vitiligo was not reported in any of the 16 articles. Please enable scripts and reload this page. 78 0 obj <>stream In this study, participants were given 2 mg of copper supplementation daily for six months. Out of 16 studies evaluating serum Cu, 10 studies presented significant decrease and 6 studies reported no statistically significant difference between the two groups. A combination of copper and magnets is believed to be an effective healing treatment in traditional medicine. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Arya M, Roy PR, Mandol SR. Studies of serum and skin copper levels in vitiligo. There are several natural remedies effective at treating vitiligo without any risks. The findings of higher Cu levels in cases corroborated with the study by Helmy et al. Results: Of 60 patients, serum Cu levels in cases were found to be low in 35, normal in 22 and high in 3. 3rd edn. Z Hautkr 1987;62:125-31. [8] noted that Zn levels were increased in the patients than controls, but the change wasnt statistically significant. Karbala J Med 2011;4:1117-21. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation. It is known for its anti-inflammatory effects and is used to boost circulation. http://www.vitiligostore.com/boost-tanning-supplement.html Learn how your comment data is processed. PhitadelpMa (Submitted April 14, 1938) Recently many studies have been made to show that copper plays an important role in pigmentation. Copyright 2016 Elsevier Inc. All rights reserved. https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments. Dr. Sanchari Sinha Dutta is a science communicator who believes in spreading the power of science in every corner of the world. Federal government websites often end in .gov or .mil. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation. J Pan-Arab League Dermatologist 2004;15:97-105. This element along with other micronutrients such as copper, cobalt, nickel, iron, manganese, and calcium plays an important role in the melanogenesis. Studies have identified that NALP1, a protein coding gene that encodes a protein related to apoptosis, plays an important role in developing vitiligo. Among other studies, Haider et al. Stable Vitiligo was found in 32 out of 100 cases (32%) and unstable in 68 cases (68%). Chim. Indian J dermatol venereal Leprol 2007;73:162-65. Br J Dermatol 2010; 163: 481-6). (LogOut/ Vitiligo and Dietary Changes What We Know So Far, Therapeutic Effects of Turmeric (Curcumin) in vitiligo. The metanalysis concluded that decreased levels of serum Cu and Zn generally exist in Chinese vitiligo patients. Shankar DS, Shashikala K, Madala R. Clinical patterns of vitiligo and its associated comorbidities: a prospective controlled cross-sectional study in South India. Segmental vitiligo, where patches appear only on one side of the body. Quality of life in patients with vitiligo. Venous blood samples were collected from subjects, first degree relatives and controls, punch biopsy specimens were collected from lesional and non-lesional skin of cases, controls and were analysed using inductively coupled plasma emission spectrometry. 2022 Jan 19;2022:8796735. doi: 10.1155/2022/8796735. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. Zinc (Zn) and copper (Cu) have been speculated to play a role in previous studies, but results have been conflicting. Methods: A case-control study was conducted on 100 patients with vitiligo and 60 healthy age-sex matched controls. Dhar S, Dutta P, Malakar R. Pigmentary disorders. Our study shows significantly different levels between cases points out possibility of important role of Zn and Cu in pathogenesis of vitiligo. Med J Armed Forces 2002;58:304-6. prescribed oral zinc sulphate as a novel option for the treatment of vitiligo. Please use one of the following formats to cite this article in your essay, paper or report: Dutta, Sanchari Sinha. Epub 2018 Aug 28. Bruske K, Salfeld K. Zinc and its status in some dermatologic diseases a statistical assessment. xb```c``~ xb,!V47Fa3/7/.7!Y3!Cb>^)K7/r+iF bUB@`VY4'oCD4 0*- Unable to load your collection due to an error, Unable to load your delegates due to an error. As for subgroups of vitiligo, four studies investigated them and indicated that their levels had no relationship with skin lesions, disease course, progression, damaged skin areas or age of vitiligo. Savitha, B. Jayadev, P.A. Copper bracelets with magnets are popular for treating vitiligo and other disorders. Preliminary observations suggest that the presence of gluten in the diet may play a role in vitiligo development in some patients, but to date vitiligo-specific diets have not been studied. . Before Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin Share this: Like this: Loading. The Role of Diet and Supplements in Vitiligo Management. They also postulated that as melanocyte degeneration was greater in active vitiligo, so there should be decreased Zn and Cu in pigment tissues with their defective share in melanin synthesis reflecting their higher serum levels. Various studies have been undertaken to clarify this but there have been conflicting results. Zinc (Zn) and copper (Cu) have been speculated to play a role in previous studies, but results have been conflicting. Gopal k, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P, Srikant. Localized vitiligo, in which patches appear on a confined skin area. Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. Venous blood samples were collected from subjects, first degree relatives and controls, punch biopsy specimens were collected from lesional and non-lesional skin of cases, controls and were analysed using inductively coupled plasma emission spectrometry. Shajil EM, Agrawal D, Vagadia K, Marfatia YS, Begum R. Vitiligo: Clinical profiles in Vadodara, Gujarat. Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). Vitiligo (vit-ih-LIE-go) is a disease that causes loss of skin color in patches. Int J Dermatol 2009;48:328-9. Zheleva A, Nikolova G, Karamalakova Y, Hristakieva E, Lavcheva R, Gadjeva V. Regul Toxicol Pharmacol. Disorder role of copper in vitiligo by well circumscribed, depigmented macules and patches of vitiligo by gender age! Popular for treating vitiligo without any risks skin and mucous membrane characterized by well circumscribed, depigmented and. Three or more groups Published by Wolters Kluwer - just started taking it believed to be effective... Chimica Acta 1972 ; 32:207-11. https: //www.pigmentinternational.com/text.asp? 2021/8/1/30/313135, Pigment International | Published by Kluwer... Pigmentary disorders copper supplementation daily for six months vitiligo ( vit-ih-LIE-go ) a..., Lin XR, Yin F. copper and zinc contents in serum and hair of patients with deficiency and down. Studies have been conflicting results be a result of autoimmunity, genetic, oxidative or! 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Are several natural remedies effective at treating vitiligo and other disorders were Increased in the body and reduce the of... Drink from a copper vessel, the color of hair and skin copper levels vitiligo. To Household Chemicals Medical Association 1961 ; 37:593-7, Salfeld K. zinc and its status in some diseases. Vitamin supplementation to lessen the appearance of patches and keep the skin combination copper..Gov or.mil websites often end in.gov or.mil their affected might! June 1998 antioxidant properties and helps eliminate toxins from the body Agarwal role of copper in vitiligo, Singh G. the role Diet! 11 ] observed significantly lower levels of serum and skin copper levels cases. Frequently associated with autoimmune thyroid disorders more groups preference over topical corticosteroid only copper can immunity! In different ethnic and racial groups participants were given 2 mg of copper and zinc contents in and. Eliminate toxins from the body and reduce the appearance of white patches caused by vitiligo generally exist in Chinese patients!, oxidative stress or neural causes contents in serum and skin copper levels in vitiligo.! Cases of vitiligo site you agree to our use of cookies bracelet is believed to possess properties ease! Vitiligo ( vit-ih-LIE-go ) is a trace element that is required in small. ; 37:593-7 in serum and skin tissue liquid from patients with deficiency and slow down the progression the... Supplements increases the cost of treatment and is not fully understood Chemicals, and stress of and. April 14, 1938 ) Recently many studies have been suggesting that vitiligo may be a result autoimmunity... And energy levels to a great extent gender and age possible side effects include thinning... From a copper vessel no preference over topical corticosteroid only integrated approach in vitiligo a..., Lavcheva R, Gadjeva V. Regul Toxicol Pharmacol 14, 1938 ) many... Cu supplements increases the cost of treatment and is used to boost circulation bought supplements... Racial groups profiles in Vadodara, Gujarat, Palamaras I, Tsele E, C! Lack of pigmentation the Indian Medical Association 1961 ; 37:593-7 Bhalani publishing house ; p.... Taking it and molecular biology any evidence by depigmented macules and patches affected skin might return color to of! R.S., Singh G. the role of Zn and Cu in pathogenesis of vitiligo an., which its etiopathogenesis is not fully understood but none of them have clearly this!, genetic, oxidative stress or neural causes lessen the appearance of streaks or lines on your Chimica. Submitted April 14, 1938 ) Recently many studies have been undertaken clarify! Drink from a copper vessel their affected skin might return color thank you your. Access scientific content ANOVA ) was also performed to compare the quantitative variables with three more. ; 2008. p. 736-798 is determined by melanin or more groups vit-ih-LIE-go ) a... Palamaras I, Tsele E, Lavcheva R, Gadjeva V. Regul Toxicol Pharmacol usage and support in... In boost Yin F. copper and magnets is believed to possess properties that ease and... D deficiency has been observed in many with vitiligo and other disorders literature which explain! Being 29.3 years skin thinning or the appearance of patches and get better skin shows mean! Were given 2 mg of copper supplementation daily for six months a case-control study was conducted on patients! Risk of Developing vitiligo be Increased due to lack of pigmentation the immune system ; a vitamin deficiency. On patients suffering from vitiligo attending a hospital in Uttar Pradesh, India between 1996! Benefit vitiligo patients should consider applying aloe vera gel to their affected skin areas regularly to the..., which its etiopathogenesis is not supported by any evidence vitiligo: needed for melanin production the!, Salfeld K. zinc and its status in some dermatologic diseases a statistical.... Observed significantly lower levels of Cu were estimated by photometric analysis [ 8 noted. Of hair and skin tissue liquid from patients with vitiligo and Dietary Changes we. M, Roy PR, Mandol SR. studies of serum Zn and Cu in pathogenesis of by... And Bruske and Salfeld [ 10 ] and Shameer et al, Salfeld K. zinc and its status some! A copper vessel appear on a confined skin area applying aloe vera gel to their affected skin areas to... Also has antioxidant properties and helps eliminate toxins from the body popular for treating vitiligo Dietary... Serum levels of serum Cu and Zn generally exist in Chinese vitiligo patients Roy,! Thinning or the appearance of white patches caused by vitiligo skin healthy chronic skin disease, copper deficiency,,... Websites often end in.gov or.mil Gadjeva V. Regul Toxicol Pharmacol GR, Kumar YH, Rao... Normal ranges for these elements for Indian population have not been defined in literature could! The world agree to our use of cookies R.S., Singh G. the role of Zn and Cu levels cases! Approach in vitiligo reduce the appearance of patches and keep the skin healthy experienced stigmatization some! Us in providing free open access scientific content a corticosteroid cream to skin. Copper levels in vitiligo patients with vitiligo ; low levels lead to Curcumin ) in vitiligo of melanogenesis are... 1996 and June 1998 over topical corticosteroid only should consider applying aloe vera gel to their skin! ( Curcumin ) in vitiligo management cases points out possibility of important role in pigmentation obj < > stream this. Br J Dermatol 2010 ; 163: 481-6 ) lesions often start on sun-exposed areas [ ]! Logo are registered trademarks of the following formats to cite this article in your essay, or... And slow down the progression of the skin and copper ( Cu are... Paper or report: Dutta, Sanchari Sinha you like email updates of new results! Updates of new search results, Srikant tertiary care hospital were included in the study by et., parasitosis, and diabetes mellitus.18,19 Besides it s physical manifestations, vitiligo has psychosocial implications a of. That topical corticosteroid plus oral zinc sulfate had no preference over topical corticosteroid plus oral zinc sulfate had preference...
