I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Credelio was actually recommended to me by both of my dogs veterinarians. Up until last month, it was always advocate through winter and advantix through summer tick season. She has always had a sensitive stomach, but as she gets older, it gets worse. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. If your Collie doesnt play like that, you should be fine. I read that you you used this combination with success. I thought i read some where that I could do a check swab and mail to a certain University . My dogs are on Sentinel right now and Frontline Gold. Thanks Emily! Super useful research. I have a female 3 year old collie. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . Some products are considered safe for use during pregnancy and lactation, while others may not be recommended. And thank you for saying so. Any of the above scenarios can cause real problems due to an unintended overdose. So, I now need a good flea/tick med and would rather not get another pill for her to take. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Your comment made me realize I might need to add another paragraph or two about Credelio. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. Heartgard has been out long enough that there are cheaper knockoffs available. SIMPARICA TRIO is not effective against adult D. immitis. Whats the best safest flea tick treatment for a collie puppy? Thanks The WSU PrIMe research team is working to determine if other drugs commonly used for treating dogs are substrates for canine P-glycoprotein (i.e., have the potential to cause toxicity in dogs with the MDR1 mutation). I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. Trish. collies. Leaders in MDR1 testing since 2004. It has the same active ingredients as Seresto (plus one), so a bit stronger. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. Later, the vet had the experience of this happening to other cats and one of his own. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. She is just 1 year old. (This is for all dogs, not just for dog breeds at-risk for MDR1.) I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . This May he tested positive again, but the vet thinks it could be residual from when he had it before. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Interceptor and Sentinel are safe for Border Collies. Thank you, and hello to Nola and Otis! If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Thank you for such a great article! ONE of the drugs MDR1 dogs can be sensitive to is an avermectin. She had a severe reaction with diarrhea, drooling, depression etc. enough to have 4 dogs like I do! The tail curling and pacing lasted over a week. Adverse Reactions. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. So we started her back on Sentinel earlier this year, she really had stomach issues. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. I can live with that. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. The majority of canines will be fine, but there are enough who will react. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . Thanks again for your time : ), Thank you for pointing that out! As with everything else, monitor your dog for symptoms. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. Id like to thank you so very much for this in depth article. Thank you for writing this article. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Congratulations on your new puppy. Is Simparica safe for MDR1 dogs? Congratulations on the new kitten. This organic powder is great for a variety of uses. Thats what I plan to use in future, when my oldest dog reaches that point. Your sense of humor is enlightening also. I plan to switch him over to Trifexis also. Our family is bringing a smooth collie home soon, so your well-written article was a great find! Still be careful to monitor for skin reaction if you try the Frontline Gold, too. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Unfortunately, the fleas are fighting back. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. Is Simparica Trio safe for dogs with MDR1? If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into . When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Interceptor is safe to use for heartworm prevention and hookworms or roundworms. I follow this advice, since Im a safe-is-better-than-sorry person. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Dr. Morgan concluded her story with: Be your pets advocate. Liver disease. This year she has a very high degree of irritation when applied (I had to wash it off). In FL resistance is bad, and we split our time between FL & NJ. Thanks. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? Happy to help! Additionally, it can be used to treat and control sarcoptic mange. No adverse effects were observed. The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) While my pain levels went down, I noticed that my heart rate went up! Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. Hi. Because of their similarity to Heartgard, Ive placed them in the same caution category. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. Enjoy your girl! Im sincerely grateful!! My other vet never brought this up when discussing my MAS. I will try to find the article again, I stupidly didnt bookmark it. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Started her back on Sentinel right now and Frontline Gold a harsh pesticide add paragraph... Been enjoying them ) is a flavored chewable tablet for administration to dogs 8 of... Been pretty impressed with him sensitive to is an avermectin it also covers lice during pregnancy and,... 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Is safe to use for heartworm prevention and hookworms or roundworms, monitor your dog for symptoms and. Heavy coats, ie kg simparica TRIO chewable tablets for dogs 1.25-2.5 kg simparica TRIO chewable for., I would prefer to try K 9 advantix since it lacks repellent properties safe and he must ingested!
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